These grant followed the international trend to employ the computational technologies to solve real problems from the medical field when experimental methods are too expensive or cannot reach the goals. The first part of the research process was the computational modeling of several knee implants types and the creation of a material properties database used for implants manufacturing. Using the kinetics and kinematics data obtained with non-invasive methods from patients, the behavior of the total knee implants was studied for several physical activities using finite elements method. The objective of this part was to obtain the stress/strain distribution and material changes evaluation due to the fatigue and wear of the prosthesis contact surfaces. An important part of the research was focused on studying the influence of the stiffness of the implant material on bone remodeling at the interface between bone and implant material through stress distribution and micro-motion at the interface, an important factor in prosthesis failure.

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